Objectives

Develop a continuous antisolvent crystallization process integrated with hydrodynamic cavitation to investigate effects on the crystal size distribution and process performance.

Key findings

• The performance of a continuous stirred crystallizer was augmented using a loop configuration
• Use of vortex-based hydrodynamic cavitation enhanced nucleation and breakage
• Developed a population balance model to simulate nucleation, growth, and breakage
• The model was applied and validated for the optimization of crystallizer performance

Relevance

Provides a scalable and energy-efficient strategy for producing smaller, more uniform pharmaceutical crystals while maintaining high yield and productivity in continuous manufacturing.

Objectives

Investigate hydrodynamic cavitation-induced breakage of non-spherical crystals and develop a modeling framework to predict crystal size and shape in such systems.

Key findings

• A vortex-based hydrodynamic cavitation device reduced the length and width of carbamazepine dihydrate crystals
• Breakage showed fast and slow regimes, with most size reduction in 20 passes
• Developed correlations to predict crystal size reduction as a function of operating conditions
• The developed population balance model (one-dimensional) simulated breakage (length and width) across conditions

Relevance

Provides an energy-efficient alternative to conventional milling for tailoring pharmaceutical crystal size and shape while preserving crystal form and morphology.

Objectives

Insert 2-3 lines elaborating on the objective of the current work.

Key findings

• Finding 1
• Finding 2
• Finding 3
• Finding 4

Relevance

The relevance of the current work.

Objectives

Investigate the use of hydrodynamic cavitation to enhance nucleation and intensify continuous antisolvent crystallization of paracetamol.

Key findings

• Demonstrated use of Hydrodynamic Cavitation (HC) to enhance nucleation for the first time
• Developed a correlation to quantify the effect of HC on induction time
• HC-assisted nucleation led to a significant reduction in encrustation and fouling
• Use of HC-assisted pre-nucleator before the continuous tubular crystallizer improved yield and productivity

Relevance

Provides a scalable and energy-efficient strategy to enhance nucleation, reduce fouling, and significantly improve yield and productivity in continuous pharmaceutical crystallization.

Objectives

Insert 2-3 lines elaborating on the objective of the current work.

Key findings

• Finding 1
• Finding 2
• Finding 3
• Finding 4

Relevance

The relevance of the current work.

Objectives

Insert 2-3 lines elaborating on the objective of the current work.

Key findings

• Finding 1
• Finding 2
• Finding 3
• Finding 4

Relevance

The relevance of the current work.

Objectives

To investigate the influence of non-Newtonian, specifically shear-thinning fluid behavior, on the flow characteristics and cavitation inception in a vortex-based hydrodynamic cavitation device (VD) using experimental measurements and CFD simulations.

Key findings

• Increasing digestate solids content and effective viscosity reduced pressure drop and weakened swirl intensity in VD
• Higher effective viscosity delayed cavitation inception, increasing the inception pressure drop compared with water
• CFD simulations showed good agreement with experimental pressure drop and velocity measurements for water and digestate slurries
• Cavitation inception occurred at a critical tangential velocity of approximately 10 m/s, largely independent of fluid rheology

Relevance

Provide a foundation for the design and optimization of VD for processing complex fluids and slurries encountered in waste valorization and bioprocessing applications.

Objectives

Insert 2-3 lines elaborating on the objective of the current work.

Key findings

• Finding 1
• Finding 2
• Finding 3
• Finding 4

Relevance

The relevance of the current work.